Letter to the Editor
Coronavirus disease 2019 (COVID-19) is associated with a high fatality rate in patients requiring invasive mechanical ventilation (IMV). COVID-19-related acute respiratory distress syndrome (COVID-ARDS) might exhibit vascular insults, resulting in loss of hypoxic pulmonary vasoconstriction, and subsequent dissociation between profound hypoxemia and preserved static compliance of the respiratory system (Cst-rs). Experts recently distinguished two phenotypes of COVID-ARDS according to their Cst-rs: patients were classified as groups L (low elastance (or high Cst-rs) and low recruitability) and H (high elastance and high recruitability). They recommended different ventilatory approaches, contrary to Sepsis Surviving Campaign guidelines. We describe characteristics and outcomes in patients with different initial Cst-rs, but all receiving IMV following ARDS guidelines.